3,4-Difluorobenzoic acid → HCID 18673933, compound

HRID 1635983Notes

Reaction equation

HRID 1635983 reaction equation
FC1C=C(C=CC=1F)[C:5](O)=[O:6].[NH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26](=O)[CH3:27])=[N:17][CH:18]=1>>[NH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:21]=2[CH2:26][CH2:27][C:5]3=[O:6])=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 991663,4-Difluorobenzoic acidHCID 18673961HCID 18673961, compound

Product 1

HCID 18673933HCID 18673933, compound

Procedure

According to the same manner as that described in Example 1 except for using an equimolar amount of 3,4-difluorobenzoic acid in place of 3,4-dichlorobenzoic acid and using an equimolar amount of 1-{2-[(5-amino-2-pyridinyl)oxy]phenyl}-1-ethanone obtained in Reference Example 23 in place of 4-[(5-amino-2-pyridinyl)oxy]-1-indanone, the reaction was carried out to obtain the titled compound.

Sources & evidence

ORD record
ord-8ccf5d66bbd44992b186bae1f58d4699
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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