3,4-Difluorobenzoic acid → HCID 18673933, compound

HRID 1635985Notes

Reaction equation

HRID 1635985 reaction equation
FC1[CH:3]=[C:4](C=CC=1F)[C:5](O)=[O:6].[NH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]2[CH:25]=[CH:24][C:23](C(C3C=CC=CC=3)=O)=[CH:22][CH:21]=2)=[N:17][CH:18]=1>>[NH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]2[CH:21]=[CH:22][CH:23]=[C:24]3[C:25]=2[CH2:3][CH2:4][C:5]3=[O:6])=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 991663,4-Difluorobenzoic acidHCID 511930HCID 511930, compound

Product 1

HCID 18673933HCID 18673933, compound

Procedure

According to the same manner as that described in Example 1 except for using an equimolar amount of 3,4-difluorobenzoic acid in place of 3,4-dichlorobenzoic acid and using an equimolar amount of {(4-[(5-amino-2-pyridinyl)oxy]phenyl}(phenyl)methanone obtained in Reference Example 25 in place of 4-[(5-amino-2-pyridinyl)oxy]-1-indanone, the reaction was carried out to obtain the titled compound.

Sources & evidence

ORD record
ord-7424fd97437f4473b268d73d96606120
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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