3,4-Difluorobenzoic acid → HCID 18673933, compound

HRID 1635986Notes

Reaction equation

HRID 1635986 reaction equation
FC1[CH:3]=[C:4](C=CC=1F)[C:5](O)=[O:6].CC1([C:18]2[CH:31]=[CH:30][C:21]([O:22][C:23]3[N:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=3)=[CH:20][CH:19]=2)OCCO1>>[NH2:29][C:26]1[CH:25]=[CH:24][C:23]([O:22][C:21]2[CH:20]=[CH:19][CH:18]=[C:31]3[C:30]=2[CH2:3][CH2:4][C:5]3=[O:6])=[N:28][CH:27]=1

Participants

3

Reactant 2

HCID 991663,4-Difluorobenzoic acidHCID 18673940HCID 18673940, compound

Product 1

HCID 18673933HCID 18673933, compound

Procedure

According to the same manner as that described in Example 1 except for using an equimolar amount of 3,4-difluorobenzoic acid in place of 3,4-dichlorobenzoic acid and using an equimolar amount of 6-[4-(2-methyl-1,3-dioxolane-2-yl)phenoxy]-3-pyridinylamine obtained in Reference Example 35 in place of 4-[(5-amino-2-pyridinyl)oxy]-1-indanone, the reaction was carried out to obtain the titled compound.

Sources & evidence

ORD record
ord-ef39e83807a84e2e9f531b2f315a3467
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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