4-(Trifluoromethyl)benzoic acid → HCID 18673933, compound

HRID 1635987Notes

Reaction equation

HRID 1635987 reaction equation
FC(F)(F)C1C=C[C:6]([C:7](O)=[O:8])=[CH:5]C=1.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][C:22]2[CH:27]=[CH:26][C:25](C(O)C)=[CH:24][CH:23]=2)=[N:19][CH:20]=1>>[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][C:22]2[CH:23]=[CH:24][CH:25]=[C:26]3[C:27]=2[CH2:5][CH2:6][C:7]3=[O:8])=[N:19][CH:20]=1

Participants

3

Reactant 2

HCID 99664-(Trifluoromethyl)benzoic acidHCID 18673880HCID 18673880, compound

Product 1

HCID 18673933HCID 18673933, compound

Procedure

According to the same manner as that described in Example 1 except for using an equimolar amount of 4-(trifluoromethyl)benzoic acid in place of 3,4-dichloro benzoic acid and using an equimolar amount of 1-{4-[(5-amino-2-pyridinyl)oxy]phenyl)-1-ethanol obtained in Reference Example 37 in place of 4-[(5-amino-2-pyridinyl)oxy]-1-indanone, the reaction was carried out to obtain the titled compound.

Sources & evidence

ORD record
ord-090bf3ca50434c259b252b775aad79d2
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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