4-(Trifluoromethyl)benzoic acid → HCID 18673933, compound

HRID 1635989Notes

Reaction equation

HRID 1635989 reaction equation
FC(F)(F)C1C=CC(C(O)=[O:8])=CC=1.C[C:15]1[CH:16]=[CH:17][C:18]([O:24][C:25]2[N:30]=[CH:29][C:28]([NH2:31])=[CH:27][CH:26]=2)=[C:19]2[C:23]=1[CH2:22][CH2:21][CH2:20]2>>[NH2:31][C:28]1[CH:27]=[CH:26][C:25]([O:24][C:18]2[CH:17]=[CH:16][CH:15]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:8])=[N:30][CH:29]=1

Participants

3

Reactant 2

HCID 99664-(Trifluoromethyl)benzoic acidHCID 18673908HCID 18673908, compound

Product 1

HCID 18673933HCID 18673933, compound

Procedure

According to the same manner as that described in Example 1 except for using an equimolar amount of 4-(trifluoromethyl)benzoic acid in place of 3,4-dichlorobenzoic acid and using an equimolar amount of 6-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-pyridinylamine obtained in Reference Example 29 in place of 4-[(5-amino-2-pyridinyl)oxy]-1-indanone, the reaction was carried out to obtain the titled compound.

Sources & evidence

ORD record
ord-184167144e9046a3866ee7b40a5c89ee
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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