反应详情

Warfarin sodium is prepared by refluxing the pure warfarin acid with an excess of sodium carbonate in a polar solvent such as acetone or butanone, which may be either anhydrous or contain from about 1% to about 10% water. The unreacted sodium carbonate is preferably removed by filtration. The product is isolated by evaporating the solvent to dryness or by precipitating the salt by addition of a nonpolar solvent such as hexane, cyclohexane, heptane and the like, and filtering and drying the precipitate.

1. customThe unreacted sodium carbonate is preferably removed by filtration
2. customThe product is isolated
3. customby evaporating the solvent to dryness
4. customby precipitating the salt
5. additionby addition of a nonpolar solvent such as hexane, cyclohexane, heptane
6. filtrationthe like, and filtering
7. customdrying the precipitate