Hydromorphone → Hydromorphone Hydrochloride

Participants

Reaction Steps

The hydromorphone base (15.0 g) was dissolved in methanol/DI water (14 mL, 50/50 by volume) and concentrated HCl/ water (10 mL, 50/50 by volume). The solution was filtered and n-propanol (42 mL) was added. The suspension was stirred overnight, filtered, and vacuum dried. The dried hydromorphone hydrochloride (12.9 g; 30% yield) contained 0.7% 8-hydroxyhydromorphone and 0.1% dihydromorphine. The hydromorphone hydrochloride failed the Readily Carbonizable Substances test.

Provenance & Evidence