HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-Ac-D-Phe-2-Nal-OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-Ac-D-Phe-2-Nal-OMe | HCID 73937193 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | N-Ac-D-Phe-2-Nal-OH | HCID 73916679 | 113.5% |
Reaction Steps
A solution of N-Ac-D-Phe-2-Nal-OMe (1.55 g) in 20 ml of dioxane/water=9/1 (v/v) was treated with sufficient 6N sodium hydroxide to keep the pH at 12 for 1 hours at room temperature. After acidification, the mixture was poured into water and was extracted with dichloromethane. The organic layer was washed with water and was dried on sodium sulfate. The filtrate was evaporated and yielded 1.7 g crude N-Ac-D-Phe-2-Nal-OH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06034067 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-b46995fb7d15494782325407a5877dac |
| Source note | uspto-grants-2000_03 |