1-(2-Pyrimidinyl)piperazine → HCID 464016, compound

Participants

Reaction Conditions

Reaction Steps

In 20 ml of pyridine were dissolved 1.0 g (0.003 mole) of 1-cyclopropyl-6,7-difluoro-8-trifluoromethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 1.23 g (0.0075 mole) of 1-(2-pyrimidinyl)piperazine, and the mixture was stirred at 105° C. for 3 hours. Then, the solvent was removed by evaporation under reduced pressure, and the residue was applied to silica gel column chromatography (eluent; a chloroform:methanol=9.5:0.5 mixed solution) to obtain 0.68 g of 1-cyclopropyl-6-fluoro-8-trifluoromethyl-1,4-dihydro-4-oxo-7-[4-(2-pyrimidinyl)piperazin-1-yl]quinoline-3-carboxylic acid as yellow powder.

Provenance & Evidence