2-Morpholinoethanol → HCID 15887896, compound

Participants

Reaction Steps

To 5 ml of methylene chloride were added 100 mg (0.21 mmole) of 2-cyclopropyl-6-fluoro-8-trifluoromethyl-1,4-dihydro-4-oxo-7-[4-(2-pyridyl)piperazin-1-yl]quinoline-3-carboxylic acid, 0-055 g (0.42 mmole) of 4-(2-hydroxyethyl)morpholine, 0.045 g (0.37 mmole) of 4-dimethylaminopyridine and 0.091 g (0.48 mmole) of 1-ethyl-3-(3-dimethyaminopropyl)carbodiimide hydrochloride, the mixture was left to stand at room temperature for 7 days, and then the solvent was removed by evaporation under reduced pressure. The residue was applied to column chromatography (eluent; a chloroform:methanol:28% aqueous ammonia=40:9:1 mixed solution) to obtain 60 mg of 1-cyclopropyl-6-fluoro-8-trifluoromethyl-1,4-dihydro-4-oxo-7-[4-(2-pyridyl)piperazin-1-yl]quinoline-3-carboxylic acid 2-morpholinoethyl ester as pale yellow powder.

Provenance & Evidence