Pyridine → HCID 19350837, compound

HRID 1636285Notes

Reaction equation

HRID 1636285 reaction equation
[CH2:1]([O:8][CH2:9][CH:10]([CH2:12][O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])[OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[S:27](Cl)([CH3:30])(=[O:29])=[O:28]>O>[CH2:1]([O:8][CH2:9][CH:10]([CH2:12][O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:15])[CH3:16])[O:11][S:27]([CH3:30])(=[O:29])=[O:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 156217871-O-benzyl-3-O-t-butyldimethylsilylglycerol

Product 1

HCID 19350837HCID 19350837, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
5 °C

Procedure

1-O-benzyl-3-O-t-butyldimethylsilylglycerol (1.63 g) was added to pyridine (6 ml), and the mixture was cooled to 5° C., and mesyl chloride (0.5 ml) was added dropwise thereto, and the resultant mixture was stirred overnight at room temperature. Upon confirming the completion of the reaction, the reaction liquid was cooled to 5° C., water (0.5 ml) was added thereto and the mixture stirred at the same temperature for 30 minutes.

Workup

  1. customthe completion of the reaction
  2. customthe reaction liquid
  3. temperaturewas cooled to 5° C.

Sources & evidence

ORD record
ord-7fb5176800de49cebbe66ff59e10b14b
Source dataset
uspto-grants-2000_03
Patent number
US06034087

Reaction notes

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