Ethyl Thioglycolate → 1-O-benzyl-3-O-t-butyldimethylsilyl-2-(ethoxycarbonylmethylthio)glycerol

Participants

Reaction Conditions

Reaction Steps

1-O-benzyl-3-O-t-butyldimethylsilyl-2-O-mesylglycerol (0.83 g) was dissolved in N,N-dimethylformamide (5 ml), and ethyl thioglycolate (0.34 ml) and sodium ethoxide (sodium 0.07 g/ethanol 5 ml) were added thereto, and the mixture stirred at 80° C. for 6 hours. After removing the solvent by evaporation under reduced pressure, water was added to the residue and the solution was extracted with ethyl ether (20 ml×3).

Provenance & Evidence