2-Mercaptoethanol → HCID 178508214, compound

Participants

Reaction Steps

2-Amino-6-chloro-9-(5-hydroxymethyl-1,4-oxathian-2-yl)purine (0.03 g) was dissolved in methanol (10 ml), and 2-mercaptoethanol (0.03 ml) and 1M, sodium methoxide solution (0.01 ml) were added thereto. The resultant mixture was stirred under reflux for three days. After concentrating the reaction mixture under reduced pressure, water was added thereto, and the aqueous layer was washed several times with ethyl ether. Acetic acid was added thereto to adjust pH of the aqueous layer to 7, and the solvent was distilled off under reduced pressure. The residue was purified on a silica gel column (eluent: chloroform/methanol=5/1) to obtain the desired product (0.02 g) as pale yellow solid.

Provenance & Evidence