HCID 54127341, compound → HCID 19350794, compound

Participants

Reaction Steps

Hydroxy acid (2.34 g) obtained from Example 27 was dissolved in benzene (400 ml), and concentrated sulfuric acid (4 drops) was added thereto. The reaction mixture was stirred under reflux for 2 hours as removing water by Dean-Stark trap to complete the reaction. The reaction mixture was washed with water and saturated brine sequentially and dried over anhydrous magnesium sulfate. Upon concentrating the reaction mixture under reduced pressure, lactione (2 g) was obtain as oil.

Provenance & Evidence