Acetyl chloride → HCID 54052838, compound

HRID 1636308Notes

Reaction equation

HRID 1636308 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]=[N:12][N:13]2[CH:17]=[N:16][NH:15][C:14]2=[O:18])[CH:6]=1>N1C=CC=CC=1>[C:1]([N:15]1[C:14](=[O:18])[N:13]([N:12]=[CH:11][C:7]2[CH:6]=[N:5][CH:10]=[CH:9][CH:8]=2)[CH:17]=[N:16]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 54560653HCID 54560653, compound

Product 1

HCID 54052838HCID 54052838, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.4 g of acetyl chloride are added to a suspension of 3.8 g of 4-(pyridin-3-ylmethyleneamino)-1,2,4-triazol-3-one in 50 ml of pyridine. The resulting solution is stirred for 14 hours at 20° and then concentrated by evaporation. Water is added to the residue and extraction is carried out with chloroform. The organic phase is concentrated by evaporation and the residue is stirred with ether. The crystals are filtered off with suction and then dried under a high vacuum. 4 g of the title compound having a melting point of 164-166° are thus obtained.

Workup

  1. concentrationconcentrated by evaporation
  2. additionWater is added to the residue and extraction
  3. concentrationThe organic phase is concentrated by evaporation
  4. stirringthe residue is stirred with ether
  5. filtrationThe crystals are filtered off with suction
  6. customdried under a high vacuum
  7. customare thus obtained

Sources & evidence

ORD record
ord-8ba73ba7b69b4cc1ad066b02c4331657
Source dataset
uspto-grants-2000_03
Patent number
US06034083

Reaction notes

Loading…