Methyl carbazate → N'-[2-(5-Methoxy-2-oxo-[1,3,4]thiadiazol-3-yl)-1-methyl-ethylidene]-hydrazinecarboxylic acid methyl ester

Participants

Reaction Steps

9.1 g of methyl carbazate are added to a solution of 18.8 g of 5-methoxy-3-(2-oxo-propyl)-3H-[1,3,4]thiadiazol-2-one (Comp. 7.001) in 150 ml of methanol and the mixture is then stirred at room temperature for 36 hours. The reaction mixture is concentrated by evaporation and the residue is stirred with isopropanol and filtered with suction to yield 20.5 g of crystals of the title compound having a melting point of 142-143°.

Provenance & Evidence