2,6-Dimethylbenzoic acid → N-Benzoyl-L-valyl-L-alanyl-L-norleucine 2,6-dimethyl benzoyloxy methyl ketone

HRID 1636327Notes

Reaction equation

HRID 1636327 reaction equation
Br[CH2:2][C:3](CBr)=[O:4].[C:7]([NH:15][C@H:16]([C:20]([NH:22][C@H:23]([C:25]([NH:27][C@H:28]([C:33]([OH:35])=[O:34])[CH2:29][CH2:30][CH2:31][CH3:32])=[O:26])[CH3:24])=[O:21])[CH:17]([CH3:19])[CH3:18])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:36][C:37]1[CH:45]=[CH:44][CH:43]=[C:42]([CH3:46])[C:38]=1[C:39]([OH:41])=[O:40]>>[CH3:2][C:3]([O:40][C:39](=[O:41])[C:38]1[C:42]([CH3:46])=[CH:43][CH:44]=[CH:45][C:37]=1[CH3:36])=[O:4].[C:7]([NH:15][C@H:16]([C:20]([NH:22][C@H:23]([C:25]([NH:27][C@H:28]([C:33]([OH:35])=[O:34])[CH2:29][CH2:30][CH2:31][CH3:32])=[O:26])[CH3:24])=[O:21])[CH:17]([CH3:18])[CH3:19])(=[O:14])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 124392,6-Dimethylbenzoic acidHCID 88025812N-Benzoyl-L-valyl-L-alanyl-L-norleucine bromomethyl ketone

Product 1

HCID 86755194N-Benzoyl-L-valyl-L-alanyl-L-norleucine 2,6-dimethyl benzoyloxy methyl ketone

Procedure

(Electrospray MS m/z 552 [MH+ ]) from of N-benzoyl-L-valyl-L-alanyl-L-norleucine bromomethyl ketone and 2,6-dimethylbenzoic acid.

Sources & evidence

ORD record
ord-6510db4c68e742ef82cab30c2404d308
Source dataset
uspto-grants-2000_03
Patent number
US06034066

Reaction notes

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