Pentafluorobenzoic acid → N-Benzoyl-L-valyl-L-alanyl-L-norleucine 2,3,4,5,6-pentafluoro benzoyloxy methyl ketone

HRID 1636329Notes

Reaction equation

HRID 1636329 reaction equation
Br[CH2:2][C:3](CBr)=[O:4].[C:7]([NH:15][C@H:16]([C:20]([NH:22][C@H:23]([C:25]([NH:27][C@H:28]([C:33]([OH:35])=[O:34])[CH2:29][CH2:30][CH2:31][CH3:32])=[O:26])[CH3:24])=[O:21])[CH:17]([CH3:19])[CH3:18])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[F:36][C:37]1[C:45]([F:46])=[C:44]([F:47])[C:43]([F:48])=[C:42]([F:49])[C:38]=1[C:39]([OH:41])=[O:40]>>[CH3:2][C:3]([O:40][C:39](=[O:41])[C:38]1[C:37]([F:36])=[C:45]([F:46])[C:44]([F:47])=[C:43]([F:48])[C:42]=1[F:49])=[O:4].[C:7]([NH:15][C@H:16]([C:20]([NH:22][C@H:23]([C:25]([NH:27][C@H:28]([C:33]([OH:35])=[O:34])[CH2:29][CH2:30][CH2:31][CH3:32])=[O:26])[CH3:24])=[O:21])[CH:17]([CH3:18])[CH3:19])(=[O:14])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 11770Pentafluorobenzoic acidHCID 88025812N-Benzoyl-L-valyl-L-alanyl-L-norleucine bromomethyl ketone

Product 1

HCID 86755198N-Benzoyl-L-valyl-L-alanyl-L-norleucine 2,3,4,5,6-pentafluoro benzoyloxy methyl ketone

Procedure

(Electrospray MS m/z 614 [MH+ ]) from of N-benzoyl-L-valyl-L-alanyl-L-norleucine bromomethyl ketone and 2,3,4,5,6-pentafluorobenzoic acid.

Sources & evidence

ORD record
ord-374d5ae4a94441e3a3f31b5784d5f55c
Source dataset
uspto-grants-2000_03
Patent number
US06034066

Reaction notes

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