2-Hydrazinopyridine → 2,4-dihydro-2-(2-pyridyl)-5-propyl-3H-pyrazol-3-one

HRID 1636346Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][NH2:8].[CH2:9]([CH2:11][CH2:12][CH2:13][C:14](CC([O-])=O)=[O:15])[CH3:10]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[C:14](=[O:15])[CH2:13][C:12]([CH2:11][CH2:9][CH3:10])=[N:8]1

Participants

Reactant 2

HCID 786452-Hydrazinopyridine

HCID 178046443-Oxooctanoate

Product 1

HCID 140508762,4-dihydro-2-(2-pyridyl)-5-propyl-3H-pyrazol-3-one

Procedure

From the reaction of 2-pyridylhydrazine and ethylbutyrylacetate, 2,4-dihydro-2-(2-pyridyl)-5-propyl-3H-pyrazol-3-one is obtained. Subsequent reaction with 2-ethylaniline yields 4-(2-ethylanilinomethylene)-2,4-dihydro-2-(2-pyridyl)-5-propyl-3H-pyrazol-3-one, Mp 151° C.

Sources & evidence

ORD record: ord-deac46cad38943a6ae5c1a8f1232daeb
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06034099

Reaction notes

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