1,1'-Carbonyldiimidazole → HCID 19351177, compound

Participants

Reaction Steps

The compound of step A (0.7 g, 2.3 mmoles) was dissolved in 8 ml of anhydrous THF and added at 0° C. with CDI (0.46 g, 2.8 mmoles). The mixture was stirred at room temperature overnight, then hydroxylamine hydrochloride (0.2 g, 2.3 mmoles) was added thereto and stirring was continued at room temperature for a further 60 hours. The formed precipitate was filtered and suspended in 1N HCl, then stirred overnight. Upon filtration and drying under vacuum, 400 mg of the title compound were obtained (55.6% yield); m.p.=194-195° C.

Provenance & Evidence