反应详情

温度

120 °C

A stirred suspension of 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one (1 g, 2.69 mmol) and BnPh3PCI (25 mg) in 1.9 molar toluene solution of phosgene (15 mL) was heated at 120° C. overnight in a sealed tube. After removal of excess phosgene, the toluene solution was rotary evaporated to dryness to afford the chlorotormate product as a white semi-solid (1.18 g).

1. customAfter removal of excess phosgene
2. customthe toluene solution was rotary evaporated to dryness