反应详情

5 To a solution of 2-chlorobenzenesulfonic acid 3-[(3-cyanophenyl)methoxy]phenyl ester (280 mg, 0.7 mmol), as prepared in the preceding step, in methylene chloride (10 mL) was added 37% HCl in ethanol (15 mL) at 0° C. The mixture was stirred at room temperature for 2 days. The solvent was evaporated and the residue was co-evaporated with methylene chloride several times. The residue was then dissolved in ethanol (10 nL) and ammonium carbonate (300 mg, 3.0 mmol) was added at 0° C. The mixture was stirred at room temperature overnight. The reaction mixture was diluted with methylene chloride (150 mL), washed with 10% K2CO3 (2×50 mL), and dried over K2CO3. The solvent was removed in vacuo, HCl in methanol (30 mL) was added, and then concentrated in vacuo. The residue was purified by flash chromatography (10% methanol in methylene chloride) to give the title compound as a white foam (238 mg, 75%). 1H-NMR (300 MHz, DMSO-d6) δ 5.15 (s, 2H), 6.67 (d, 1H, J=4.0 Hz), 6.81 (s, 1H), 7.03 (d, 1H, J=4.0 Hz), 7.32 (t, 1H, J=8.3 Hz), 7.58 (t, 1H, J=7.5 Hz), 7.65 (t, 1H, J=7.7 Hz), 7.75-7.94 (m, 6H), 9.27 (br s, 2H), and 9.45 (br s, 2H). Mass spectrum (MALDI-TOF, sinapinic acid matrix) calcd. for C20H17N2ClO4S: 417.1 (M+H), 439.0 (M+Na). Found: 417.4, 439.1.

1. customThe solvent was evaporated
2. dissolutionThe residue was then dissolved in ethanol (10 nL)
3. stirringThe mixture was stirred at room temperature overnight
4. washwashed with 10% K2CO3 (2×50 mL)
5. dry with materialdried over K2CO3
6. customThe solvent was removed in vacuo, HCl in methanol (30 mL)
7. additionwas added
8. concentrationconcentrated in vacuo
9. customThe residue was purified by flash chromatography (10% methanol in methylene chloride)