Methyl iodide → HCID 88151996, compound

HRID 1636511Notes

Reaction equation

HRID 1636511 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][NH:5][C:6](=[O:20])[C@H:7]([CH2:16][CH2:17][S:18][CH3:19])[NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].C[I:23]>>[I-:23].[CH3:17][SH2+:18].[CH3:1][O:2][C:3](=[O:21])[CH2:4][NH:5][C:6](=[O:20])[C@H:7]([CH2:16][CH2:17][S:18][CH3:19])[NH:8][C:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[O:10]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10853150HCID 10853150, compound

Product 1

HCID 88151996HCID 88151996, compoundYield 100%

Procedure

The compound of Example 19 (960 mg, 3 mmole) was dissolved with stirring in 6 mL of methyl iodide at room temperature. The reaction mixture was stirred for 6.5 hours over which time a gummy solid had separated. The supernatant was drawn off and the residue was dried under vacuum to give 1.41 g (100%) of the title compound as a hygroscopic foam.

Workup

  1. customhad separated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-73bb1bad8ec74933a9a0611495aefc2b
Source dataset
uspto-grants-2000_03
Patent number
US06034215

Reaction notes

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