Acetic Anhydride → NSC33006

HRID 1636559Notes

Reaction equation

HRID 1636559 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>C1C=CC=CC=1>[C:17]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:7]=1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 2344752-(4-Aminophenyl)benzothiazole

Product 1

HCID 233871NSC33006Yield 88%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 2-(4'-aminophenyl)benzothiazole (0.5 g, 2.21 mmol) in benzene (30 ml) and acetic anhydride (0.5 g) was stirred at reflux for 4 hours and then cooled. The white precipitate was filtered off and washed with benzene. Recrystallisation from ethyl acetate gave a white powder (0.52 g, 88%), m.p. 227.2-229.1° C.

Workup

  1. temperatureat reflux for 4 hours
  2. temperaturecooled
  3. filtrationThe white precipitate was filtered off
  4. washwashed with benzene
  5. customRecrystallisation from ethyl acetate

Sources & evidence

ORD record
ord-d07e4b58013547c6b16ef8db67f29a73
Source dataset
uspto-grants-2000_03
Patent number
US06034246

Reaction notes

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