Dichloroacetyl chloride → HCID 17879223, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2(4'-aminophenyl)benzothiazole (0.4 g, 1.77 mmol) in benzene (20 ml) was added dropwise dichloroacetyl chloride (0.34 ml) at 80° C. The yellow precipitate was formed and the mixture was stirred at 80° C. for 30 minutes. The precipitate was filtered off, washed with benzene and diethyl ether to give (2-(4'-dichloroacetamidophenyl) benzothiazole hydrochloride as a yellow powder (0.56 g, 84,8%). A fine powder of the above salt (0.25 g) was treated with 10% aqueous Na2CO3 (15 ml) for 50° C. for 1 hour, the product was collected by filtration, washed with water and dried to afford a white powder (0.2 g, 88.6%), m.p. 223.0-225.2° C.

Provenance & Evidence