反应详情

A mixture of 2-(4'-aminophenyl)benzothiazole (0.3 g, 1.32 mmol) and benzoyl chloride (0.3 ml) in pyridine (8 ml) was stirred at reflux for 2 hours, then cooled and poured into water (100 ml). The precipitate formed was filtered off, washed with water and dissolved in hot dichloromethane (12 ml). The resulting solution was cooled in an ice-bath and the solid was filtered off. The filtrate was evaporated and the residue was recrystallised from dichloromethane-methanol to give a white powder (0.36 g, 82.2%), m.p. 227.1-228.5° C.

1. temperatureat reflux for 2 hours
2. temperaturecooled
3. customThe precipitate formed
4. filtrationwas filtered off
5. washwashed with water
6. dissolutiondissolved in hot dichloromethane (12 ml)
7. temperatureThe resulting solution was cooled in an ice-bath
8. filtrationthe solid was filtered off
9. customThe filtrate was evaporated
10. customthe residue was recrystallised from dichloromethane-methanol