HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → Dodecylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Dodecylamine | HCID 13583 | — |
Reaction Steps
A solution of the acetate 11 and an amine R5R6NH in a suitable solvent such as THF, dioxane, toluene, DMF or the like, preferably THF, is treated with a suitable palladium catalyst such as tetrakis(triphenylphosphine)-palladium at a temperature of from 0° C. to about 100° C., preferably 65° C. to give the amine 12. Deprotection as above gives the amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06034251 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-72a6f30d1fea4196a39b6fa552a260f6 |
| Source note | uspto-grants-2000_03 |