反应详情

Platinum oxide (95 mg) was added to a methanol solution (50 mL) of (6S,9aR)-6-(4-chlorophenyl)-3,6,7,8,9,9a-hexahydroquinolizin-4-one (1.09 g). The resulting reaction solution was stirred under hydrogen atmosphere at room temperature for 1 hr and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: heptane-ethyl acetate system) to give 877 mg of the title compound. The physical property values of this compound were as follows:

1. customThe resulting reaction solution
2. filtrationfiltered through Celite
3. concentrationThe filtrate was concentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (eluting solvent: heptane-ethyl acetate system)