Ethanol hydrochloride → HCID 22004854, compound

HRID 1636626Notes

Reaction equation

HRID 1636626 reaction equation
C([N:3]1[C:11]2[C:6](=[C:7]3[CH2:14][CH2:13][O:12][C:8]3=[CH:9][CH:10]=2)[CH:5]([CH2:15][CH2:16][NH:17][C:18](=[O:21])[CH2:19][CH3:20])[CH2:4]1)=O.Cl.C(O)C>C(O)C>[CH2:14]1[C:7]2=[C:6]3[C:11](=[CH:10][CH:9]=[C:8]2[O:12][CH2:13]1)[NH:3][CH2:4][CH:5]3[CH2:15][CH2:16][NH:17][C:18](=[O:21])[CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 22004847HCID 22004847, compound

Product 1

HCID 22004854HCID 22004854, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of N-[2-(6-formyl-1,6,7,8-tetrahydro-2H-furo[3,2-e]indol-8-yl)ethyl]propionamide (0.18 g, 0.62 mmol.) in ethanol (5 mL) was added saturated hydrogen chloride/ethanol (15 mL). The mixture was stirred for 1.5 hours at 80° C. and then cooled. The solvent was removed in vacuo to afford the title compound as an amorphous product.

Workup

  1. temperaturecooled
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-17e639b9c9db4dc3aac5a13858125e0f
Source dataset
uspto-grants-2000_03
Patent number
US06034239

Reaction notes

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