1-(2,2-diethoxyethyl)-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]urea → 1-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2-(1H,3H)-imidazolone

HRID 1636687ノート

反応式

HRID 1636687 の反応式
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:20]=[N:19][CH:18]=[N:17]2)=[CH:12][CH:11]=1)=[O:8])C>CO.O.Cl>[N:16]1([C:13]2[CH:12]=[CH:11][C:10]([N:9]3[CH:4]=[CH:5][NH:6][C:7]3=[O:8])=[CH:15][CH:14]=2)[CH:20]=[N:19][CH:18]=[N:17]1

参加物

5

反応物 1

HCID 105917121-(2,2-diethoxyethyl)-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]urea

生成物 1

HCID 106330471-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2-(1H,3H)-imidazolone収率 77.5%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

1-(2,2-Diethoxyethyl)-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]urea (14.5 g) was dissolved in a mixture of methanol (214 ml) and water (85 ml), to which diluted hydrochloric acid (0.48 M, 104 ml) was added dropwise. After the reaction solution was stirred at room temperature for 14 hours, the precipitated crystals were collected by filtration to give 1-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2-(1H,3H)-imidazolone (8.0 g) as a colorless crystalline powder. The filtrate was concentrated under reduced pressure to about 200 ml and the precipitated crystals were collected by filtration to give an additional amount (1.08 g) of the product.

後処理

  1. additionwas added dropwise
  2. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-13bc0e7de70f45e884bb22d64b7ad97a
出典データセット
uspto-grants-2000_03
特許番号
US06034248

反応ノート

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