HCID 10609376, compound → HCID 17897644, compound

HRID 1636688Notes

Reaction equation

HRID 1636688 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH:16]=[CH:15][NH:14][C:13]3=[O:17])=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1>C(O)(=O)C.[C].[Pd]>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:16][CH2:15][NH:14][C:13]3=[O:17])=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1

Participants

4

Reactant 1

HCID 10609376HCID 10609376, compound

Product 1

HCID 17897644HCID 17897644, compoundYield 81.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Conditions

Temperature
40 °C

Procedure

1-[4-(1H-1-Tetrazolyl)phenyl]-2(1H,3H)-imidazolone (5.0 g) was dissolved in acetic acid (500 ml) and 10% palladium-carbon (50% wet, 5.0 g) was added. The resulting mixture was stirred at 40° C. for 4 hours under a hydrogen atmosphere. The catalyst was filtered and washed with acetic acid. The filtrate and the washings were combined and distilled off under reduced pressure. The residue was crystallized from ethanol to give 1-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (4.1 g) as colorless crystals.

Workup

  1. filtrationThe catalyst was filtered
  2. washwashed with acetic acid
  3. distillationdistilled off under reduced pressure
  4. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-719ede21cdf34797a4425e057826beda
Source dataset
uspto-grants-2000_03
Patent number
US06034248

Reaction notes

Loading…