反应详情

温度

100 °C

(2R,3S)-2-(2-fluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-yl)methyloxirane (2.24 g), 1-[4-(1H-1,2,4-triazol-1-yl)phenyl]-2(1H,3H)-imidazolone (2.17 g) and cesium carbonate (powder: 7.76 g) were added to dimethylsulfoxide (100 ml), and the mixture was heated with stirring at 100° C. for 17 hours. After being cooled, the reaction solution was diluted with ethyl acetate (200 ml). Ice water (200 ml) was added thereto to separate the ethyl acetate layer. The aqueous layer was extracted with ethyl acetate (100 ml). The ethyl acetate layers were combined and washed with 0.5N-sodium hydroxide (100 ml), 1N-hydrochloric acid (100 ml×2) and a saturated aqueous solution of sodium chloride (100 ml) successively. The ethyl acetate layer was dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent. The residue was purified by silica gel chromatography (eluent:ethyl acetate/acetone=4/1) to give 1-[(1R,2R)-2-(2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-[1H-1,2,4-triazol-1-yl)phenyl]-2(1H,3H)-imidazolone (Compound 38; 0.45 g).

1. temperaturethe mixture was heated
2. temperatureAfter being cooled
3. customto separate the ethyl acetate layer
4. extractionThe aqueous layer was extracted with ethyl acetate (100 ml)
5. washwashed with 0.5N-sodium hydroxide (100 ml), 1N-hydrochloric acid (100 ml×2)
6. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
7. distillationdistilled under reduced pressure
8. customto remove the solvent
9. customThe residue was purified by silica gel chromatography (eluent:ethyl acetate/acetone=4/1)