HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 5-Iodo-2-(2-methoxyethoxymethoxy)benzyl bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 5-Iodo-2-(2-methoxy-ethoxymethoxy)-benzyl alcohol | HCID 53713468 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Iodo-2-(2-methoxyethoxymethoxy)benzyl bromide | HCID 10597156 | — |
Reaction Steps
To a solution of 5-iodo-2-(2-methoxy-ethoxymethoxy)-benzyl alcohol (7.5 g, 22 mmol) in 60 mL of THF at 15° C. is added triphenylphosphine (6.35 g, 24 mmol) followed by N-bromosuccinimide (4.3 g, 24 mmol). The solution is stirred for 5 minutes. The solution is allowed to warm to ambient temperature. After 20 minutes, the solution is concentrated. The crude product is purified by column chromatography eluting with EtOAc:CH2Cl2 :hexane (3:1:6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06034093 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-407f0d08b61a423ba00d37bdb30e5fb7 |
| Source note | uspto-grants-2000_03 |