反应详情

To a solution of 3-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-hydroxy-benzonitrile hydrochloride (0.20 g, 0.75 mmol) in 3 mL of pyridine at 0° C. is added 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The solution is allowed to warm to ambient temperatures and is stirred for 6 hours. After this time, the solution is concentrated. The residue is dissolved in CH2Cl2. The organic solution is washed with 1 N HCl and saturated NaCl. The crude product is triturated with Et2O to give the title compound (0.22 g, 0.44 mmol) as a white solid.

1. temperatureto warm to ambient temperatures
2. concentrationAfter this time, the solution is concentrated
3. dissolutionThe residue is dissolved in CH2Cl2
4. washThe organic solution is washed with 1 N HCl and saturated NaCl
5. customThe crude product is triturated with Et2O