HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chlorothieno[2,3-b]pyridine-2-sulfonyl chloride → HCID 54285997, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chlorothieno[2,3-b]pyridine-2-sulfonyl chloride | HCID 18176355 | — |
| Reactant | 3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride | HCID 22870786 | — |
| Product | HCID 54285997 | HCID 54285997 | — |
Reaction Steps
The title compound is prepared from 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 1, Part E using 6-chlorothieno[2,3-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 10% EtOAc/CH2Cl2 to 25% EtOAc/CH2Cl2 to afford a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06034093 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-47226c2d084a4245bbb9b3b309ba2d06 |
| Source note | uspto-grants-2000_03 |