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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1636784Generated: October 30, 2026

5-(2-(Methylthio)-4-pyrimidinyl)-2-thiophenesulfonyl chloride → HCID 10696272, compound

https://huagongshe.com/reaction/1636784

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(2-(Methylthio)-4-pyrimidinyl)-2-thiophenesulfonyl chlorideHCID 2736995—
Reactant1-Benzothiophene-2-sulfonyl chlorideHCID 2776333—
Reactant3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochlorideHCID 22870786—
ProductHCID 10696272HCID 10696272—

Reaction Steps

The title compound is prepared from 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 1, Part E using 5-[2-(methylthio)-pyrimidin-4-yl]thiophene-2-sulfonyl chloride in a place of benzo[b]thiophene-2-sulfonyl chloride. The crude product is obtained as a white solid and is of sufficient purity to be used in the subsequent step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06034093
Source datasetuspto-grants-2000_03
ORD IDord-8f7b4ff3455f4a88bca280f54fd91cff
Source noteuspto-grants-2000_03