HuagongsheHuagongshe Chemistry Print Report · For research reference only
5'-Chloro-2,2'-bithiophene-5-sulfonyl chloride → 5'-Chloro-[2,2']-bithiophenyl-5-sulfonic acid [1-(3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5'-Chloro-2,2'-bithiophene-5-sulfonyl chloride | HCID 22017280 | — |
| Reactant | 3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride | HCID 22870786 | — |
| Product | 5'-Chloro-[2,2']-bithiophenyl-5-sulfonic acid [1-(3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide | HCID 86752312 | — |
Reaction Steps
The title compound is prepared from 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 1, Part E using 5'-chloro-[2,2']bithiophenyl-5-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The crude product is triturated with EtOAc/CH2Cl2 to yield a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06034093 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-1fc69d6b2b4c46068f0d6271c13b46b0 |
| Source note | uspto-grants-2000_03 |