反应详情

A solution of 2,2'-(5-hydroxymethyl-1,3-phenylene)di-(2-methylpropiononitrile), (3.8 g) and pyridine (1.58 g) in dichloromethane (10 ml) was stirred, and cooled in an ice bath, while thionyl chloride (3 g) was added over 10 minutes. The solution was kept at room temperature for 2 h and then heated under reflux for 1 h and evaporated to dryness under reduced pressure The residue was partitioned between water and ethyl acetate and the organic phase was separated, dried and evaporated to dryness under reduced pressure to give 2,2'-(5-chloromethyl-1,3-phenylene)di(2-methylpropiononitrile), which was used without further purification.

1. additionwas added over 10 minutes
2. temperatureheated
3. temperatureunder reflux for 1 h
4. customevaporated to dryness under reduced pressure The residue
5. customwas partitioned between water and ethyl acetate
6. customthe organic phase was separated
7. customdried
8. customevaporated to dryness under reduced pressure