Trifluoroacetic acid → HCID 15463352, compound

Participants

Reaction Steps

The compound prepared in Example 5 (155 mg, 0.34 mmol) was dissolved in DCM (2.5 ml) and TFA (3 ml) was added dropwise. After 18 h, the reaction was concentrated. The crude solid was partitioned between CHCl3 and H2O. The layers were separated and the aqueous layer was extracted with CHCl3 (2×). The combined organic layers were dried over MgSO4, filtered and concentrated to yield 130 mg of a white solid (99%). 1H-NMR (CDCl3) 2.83 (s, 3H), 5.34 (s, 2H), 7.40 (m, 5H); 13C-NMR (CDCl3)); mp-179-183° C.

Provenance & Evidence