Trifluoroacetic acid → HCID 15463356, compound

Participants

Reaction Steps

To a solution of the compound prepared in Example 8 (1.33 g, 2.94 mmol) in DCM (20 ml). was added TFA (20 ml) dropwise. After 19 hours, the reaction was concentrated under reduced pressure, and partitioned between CHCl3 and H2O. The aqueous phase basified with sat. NaHCO3, and the layers were separated. The aqueous phase was extracted with CHCl3. The combined organic layers were washed with H2O, dried over MgSO4 and concentrated under reduced pressure to yield 1.10 g (95%) of a tan solid. 1H-NMR (CDCl3) 2.76 (s, 3H) 5.23 (s, 2H), 7.20-7.60 (m, 8H), 7.93 (d, 2H, J=8.0 Hz)

Provenance & Evidence