HCID 18615105, compound → HCID 18615244, compound

HRID 1636940Notes

Reaction equation

HRID 1636940 reaction equation
Cl.[CH:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]([C:22]1[CH:23]=[CH:24][C:25]([O:31]CC2C=CC=CC=2)=[C:26]([NH:28][CH:29]=[O:30])[CH:27]=1)[OH:21].CO.C(Cl)(Cl)[Cl:42]>CO.[Pd]>[ClH:42].[CH:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]([C:22]1[CH:23]=[CH:24][C:25]([OH:31])=[C:26]([NH:28][CH:29]=[O:30])[CH:27]=1)[OH:21]

Participants

5

Reactant 2

HCID 18615105HCID 18615105, compoundHCID 21584188Chloroform methanol

Product 1

HCID 18615244HCID 18615244, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

According to the procedures as given in Example 2, the compound of Example 22 (in a solution of 40 mg of the compound in 5.8 ml of methanol) was subjected to a hydrogenolysis using 10% palladium/carbon black (27 mg), whereby the above-identified compound (28.1 mg) was obtained. Rf=0.08 (methanol/chloroform of 1/10).

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-9a139134e95147f39b54ac5992c74482
Source dataset
uspto-grants-2000_03
Patent number
US06037362

Reaction notes

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