HCID 18615253, compound → HCID 18615157, compound

HRID 1636941Notes

Reaction equation

HRID 1636941 reaction equation
[ClH:1].[CH:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]([C:22]1[CH:23]=[CH:24][C:25]([O:35]CC2C=CC=CC=2)=[C:26]([NH:28][S:29]([N:32]([CH3:34])[CH3:33])(=[O:31])=[O:30])[CH:27]=1)[OH:21].CO.C(OCC)(=O)C>CO.[Pd]>[ClH:1].[CH:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]([C:22]1[CH:23]=[CH:24][C:25]([OH:35])=[C:26]([NH:28][S:29]([N:32]([CH3:33])[CH3:34])(=[O:30])=[O:31])[CH:27]=1)[OH:21]

Participants

5

Reactant 2

HCID 18615253HCID 18615253, compoundHCID 21584119Ethylacetate methanol

Product 1

HCID 18615157HCID 18615157, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

According to the procedures as given in Example 2, the compound of Example 24 (in a solution of 40 mg of the compound in 5.1 ml of methanol) was subjected to a hydrogenolysis using 10% palladium/carbon black (24 mg), whereby the above-identified compound (38.3 mg) was obtained. Rf=0.38 (methanol/ethyl acetate of 1/3).

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-03198a5333c941b3b4961f384ca28564
Source dataset
uspto-grants-2000_03
Patent number
US06037362

Reaction notes

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