HCID 18615136, compound → HCID 18615154, compound

HRID 1636943Notes

Reaction equation

HRID 1636943 reaction equation
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][NH:17][CH2:18][CH:19]([C:21]1[CH:26]=[CH:25][C:24]([O:27]CC2C=CC=CC=2)=[C:23]([NH:35][CH3:36])[CH:22]=1)[OH:20].CO.C(Cl)(Cl)Cl>CO.[Pd]>[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][NH:17][CH2:18][CH:19]([C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([NH:35][CH3:36])[CH:22]=1)[OH:20]

Participants

5

Reactant 2

HCID 18615136HCID 18615136, compoundHCID 21584188Chloroform methanol

Product 1

HCID 18615154HCID 18615154, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

According to the procedures as given in Example 2, the compound of Example 26 (in a solution of 200 mg of the compound in 25 ml of methanol) was subjected to a hydrogenolysis using 10% palladium/carbon black (100 mg), whereby the above-identified compound (153 mg) was obtained. Rf=0.09 (methanol/chloroform of 1/10).

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-076f9a93b2b6400d9f6d32691e6c8d13
Source dataset
uspto-grants-2000_03
Patent number
US06037362

Reaction notes

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