HCID 18615222, compound → HCID 18615112, compound

HRID 1636952Notes

Reaction equation

HRID 1636952 reaction equation
[ClH:1].C([N:9]([C:14]1[CH:19]=[C:18]([CH:20]([OH:39])[CH2:21][NH:22][CH2:23][CH2:24][O:25][C:26]2[CH:38]=[CH:37][C:36]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[NH:29][C:28]=3[CH:27]=2)[C:17]([OH:40])=[CH:16][CH:15]=1)[S:10]([CH3:13])(=[O:12])=[O:11])C1C=CC=CC=1>CO.C(Cl)(Cl)Cl>[ClH:1].[CH:27]1[C:28]2[NH:29][C:30]3[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:36]=2[CH:37]=[CH:38][C:26]=1[O:25][CH2:24][CH2:23][NH:22][CH2:21][CH:20]([C:18]1[C:17]([OH:40])=[CH:16][CH:15]=[C:14]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:19]=1)[OH:39]

Participants

3

Reactant 1

HCID 18615222HCID 18615222, compound

Product 1

HCID 18615112HCID 18615112, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

According to the procedures described in Example 2, Intermediate 78 and the recovered product from the filtration (total sum of 30 mg) were treated by subjecting them to a hydrogenolysis for 13 hours using 10% palladium/carbon black (30 mg) with subsequent trituration of the resulting crude product from methanol/ethyl acetate, whereby the above-identified compound (9 mg) was obtained. Rf=0.34 (methanol/chloroform of 1/9).

Workup

  1. filtrationthe recovered product from the filtration (total sum of 30 mg)
  2. additionwere treated
  3. customfor 13 hours
  4. customwas obtained

Sources & evidence

ORD record
ord-4a421651772e4e7ab1ef0fefc5f8f238
Source dataset
uspto-grants-2000_03
Patent number
US06037362

Reaction notes

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