N-(4-methoxybenzoyl)-L-valyl-L-proline → (S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[2-methyl-1-(2,2,2-trifluoro 1-hydroxyethyl)propyl]pyrrolidine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	N-(4-methoxybenzoyl)-L-valyl-L-proline	HCID 10736489	—
Reactant	3-Amino-1,1,1-trifluoro-4-methylpentan-2-ol	HCID 14503246	—
Product	(S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[2-methyl-1-(2,2,2-trifluoro 1-hydroxyethyl)propyl]pyrrolidine-2-carboxamide	HCID 10577353	—

Reaction Steps

reaction of N-(4-methoxybenzoyl)-L-valyl-L-proline with 3-amino-4-methyl-1,1,1-trifluoro-2-pentanol to give (S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[2-methyl-1-(2,2,2-trifluoro-1-hydroxyethyl)propyl]pyrrolidine-2-carboxamide; followed by

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06037363
Source dataset	uspto-grants-2000_03
ORD ID	ord-6ff5826174d64c4baaa088822f4b284e
Source note	uspto-grants-2000_03