Methanol → HCID 19350165, compound

Participants

Reaction Conditions

Reaction Steps

20.0 g of 2-amino-2,3-dimethylbutyramide (>96%, 0.147 mol.) are dissolved at room temperature in 100 ml of H2O and 50 ml of methanol and mixed with 13.2 g of valeraldehyde (0.152 mol.). The mixture is heated for 2.5 hours at 70° C. The two-phase mixture is extracted three times at room temperature using 200 ml of MIBK each time, and the combined organic phases are concentrated in vacuo. 25.3 g (97.8% (cis/trans mixture: 25:72; no assignment) of a white solid were obtained, corresponding to a yield of 82% of the theoretical yield.

Provenance & Evidence