Monomethylamine methanol → HCID 86755220, compound

Participants

Reaction Steps

A mixture of 2-(2-acetoxymethylphenyl)-2-hydroxyiminoacetamide (1.00 g, E/Z≠65/35), a 40% methylamine/methanol solution (2.1 ml) and methanol (6.3 ml) was stirred at 40° C. for 6 hours. After the mixture was cooled by allowing it to stand, the solvent was evaporated under reduced pressure to obtain the crude product (E/Z≠98/2). This crude product was purified by column chromatography on silica gel (ethyl acetate) and crystallized from ethyl acetate-hexane to obtain the title compound as crystals (594 mg, E/Z≠93/7, yield: 67.4%).

Provenance & Evidence