HCID 21996968, compound → HCID 21996988, compound

HRID 1637025Notes

Reaction equation

HRID 1637025 reaction equation
BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[CH:20]=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]

Participants

3

Reactant 2

HCID 21996968HCID 21996968, compound2×HCID 21996975HCID 21996975, compound2×

Product 1

HCID 21996988HCID 21996988, compound

Procedure

Employing the same general procedure as for the preparation 5-bromo-2-hydroxy-4'-methylbenzophenone (Compound K), 533 mg (1.7 mmol) of 5-bromo-2-methoxy-3'-methylbenzophenone (Compound J) was converted into the title compound using 2.6 mL (2.6 mmol) of boron tribromide (1M in dichloromethane) and 15 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a white solid.

Sources & evidence

ORD record
ord-bfab717976864e4686e7160a2d759afd
Source dataset
uspto-grants-2000_03
Patent number
US06037488

Reaction notes

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