Hydrochloric Acid → HCID 21187698, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 2-(1,4-Dioxaspiro[4.5]dec-8-yl)benzonitrile (8.7 g, 35.7 mmol) in dioxane (200 mL) was added 1N HCl (200 mL) and the reaction heated to 80° C. for 2 hours. The reaction was cooled to room temperature and poured into water (1 L) the mixture was extracted with ethyl acetate (3×250 mL). The combined organics were washed with brine (200 mL) and then dried over anhydrous magnesium sulfate, filtered and concentrated at reduced pressure to give the product.

Provenance & Evidence