Hydrochloric Acid → HCID 54326757, compound

Participants

Reaction Steps

To a solution of (+/-)-methyl-3-(3-carbomethoxyphenyl)ethynyl-3-(3-cyclopentyloxy-4-methoxyphenyl)propionate (0.14 g, 0.32 mmol) in 5:2 methanol/water was added NaOH (0.01 g, 0.32 mmol). After 24 h, 3N HCl was added, the methanol was evaporated and the aqueous residue was extracted twice with CH2Cl2 and was evaporated. Purification by flash chromatography (silica gel, 5% CH3OH/CHCl3) provided the title compound as a yellow oil (0.02 g, 13%). Anal (C25H26O6 ·0.25H20) calcd: C, 70.32; H, 6.26. found: C, 70A6; H, 6.45.

Provenance & Evidence